The series revolved around teenager Peter Parker, a high school student who develops extraordinary strength and spider-like powers after being bitten by a radioactive spider. Parker decides to become a crime-fighting, costumed superhero, but must deal with family tragedies, personal problems and the insecurity of youth. As Spider-Man, Parker risks his life to fight super-powered criminals such as Doctor Octopus, Mysterio and the Green Goblin. Peter is also a freelance photographer for the Daily Bugle, but editor J. Jonah Jameson considers Spider-Man a criminal and writes front-page headlines critical of his activities.
The first season dealt primarily with Peter’s job at the Daily Bugle, focusing on his relationship with Jameson, his romance with receptionist Betty Brant, and often being called into action as his alter ego. Peter’s life, apart from the Bugle office and his Aunt May’s Forest Hills home, was rarely dealt with in early episodes. Although he was never seen at college, he would sometimes visit professors he knew (such as the opening of “Sub-Zero for Spidey”, when he went to see Professor Smartyr). Peter’s character (blue suit, yellow vest, white shirt and red tie) was designed by Steve Ditko and art consultant John Romita, Sr..
Season-one stories mainly involved classic Spider-Man villains from the comic-book series, whose captures were often accompanied by a note signed by “your friendly neighborhood Spider-Man”. Stan Lee was the story consultant for this season. Seasons two and three, produced by Ralph Bakshi, almost entirely eliminated villains from the comic book as a cost-cutting measure in favor of generic, green-skinned, magical monsters; this enabled the reuse of stock footage from Rocket Robin Hood, another animated series produced by Bakshi.