Yogi, Quick Draw, Huck and the rest of the gang encounter a variety of villains such as Captain Swashbuckle Swipe, Smokestack Smog, Lotta Litter, the Envy Brothers, Mr. Hothead, Dr. Bigot (and his henchmen Professor Haggling and Professor Bickering), the Gossipy Witch of the West, J. Wantum Vandal, the Sheik of Selfishness, Commadore Phineas P. Fibber, I.M. Sloppy, Peter D. Cheater, Mr. Waste, Hilarious P. Prankster, and the Greedy Genie, who act as their friends, hosts and/or guests, but embody some of the most common human faults and vices. Yogi and crew would often put up with them which ends with the villains either being repelled or outdone by their actions.