During this season, Roger travels to the Middle East to support the troops and gets captured by an alien hunter, Stan gets a curse that makes him age backwards and reconciles with an old flame, and Hayley and Jeff adopt a possessed baby. Guest stars of the season include Cee Lo Green, Gabourey Sidibe, Kristen Schaal, Sarah Natochenny, Anjelica Huston, Scott Foley, Sharon Lawrence, Ricky Martin, and Sarah Michelle Gellar.
Also, the hurricane-themed crossover episode with The Cleveland Show and Family Guy that would have aired the previous season but was postponed due to tornadoes in the South, aired October 2.